Mitochondria are considered the "powerhouses" of cells in the human body because they are involved in the production of cellular energy. Large amounts of energy are required for successful fertilization and embryo development. The necessary ATP content is provided by the organelles of this type, but with existing mitochondrial disorders this becomes impossible, which leads to the development of infertility.
Symptoms and manifestations
The main clinical sign of infertility due to mitochondrial mutations is the absence of pregnancy for more than 1 year in regular sexual life without the use of contraception.
Depending on the degree and characteristics of mitochondrial dysfunction, these symptoms may be of concern to some degree:
• weakness, rapid fatigue;
• decreased immunity;
• allergic reactions;
• visual or hearing impairment;
• neurological disorders, etc.
Mitochondrial disorders can also result in polycystic ovarian disease, which is accompanied by an abnormal menstrual cycle, lower abdominal pain, uterine bleeding, and other symptoms.
