Infertility due to mitochondrial disorders

Mitochondria are considered the "powerhouses" of cells in the human body because they are involved in the production of cellular energy. Large amounts of energy are required for successful fertilization and embryo development. The necessary ATP content is provided by the organelles of this type, but with existing mitochondrial disorders this becomes impossible, which leads to the development of infertility.

Symptoms and manifestations

The main clinical sign of infertility due to mitochondrial mutations is the absence of pregnancy for more than 1 year in regular sexual life without the use of contraception.

Depending on the degree and characteristics of mitochondrial dysfunction, these symptoms may be of concern to some degree:
    • weakness, rapid fatigue;
    • decreased immunity;
    • allergic reactions;
    • visual or hearing impairment;
    • neurological disorders, etc.

Mitochondrial disorders can also result in polycystic ovarian disease, which is accompanied by an abnormal menstrual cycle, lower abdominal pain, uterine bleeding, and other symptoms.

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Reasons

It is known that mitochondrial DNA is inherited exclusively through the maternal line. It is responsible for providing energy for the energy-consuming processes of oocyte fertilization and further embryo development. When mitochondrial DNA is dysfunctional, the process of conception becomes impossible due to the lack of cellular energy.
Infertility due to mitochondrial disorders occurs not only in women but also in men. Mutations of mitochondrial DNA (mtDNA) and oxidative stress lead to impaired spermatogenesis and sperm dysfunction.

Mutations of the mitochondria that lead to impaired functionality can be inherited or caused by various factors:
    • toxic effects on the body;
    • uncontrolled intake of certain medications;
    • complications of vaccination;
    • infectious diseases;
    • long-term chronic pathologies;
    • unfavorable environmental situation.

Diagnostic methods

If infertility is suspected due to mitochondrial disorders, both partners are examined at the VIVERE CLINIC. For diagnosis, we use modern techniques and technology to understand the reasons for the absence of pregnancy.

The examination program is primarily aimed at detecting mitochondrial dysfunction and includes a number of laboratory tests. All necessary tests, including specific ones, can be taken at our clinic. We also cooperate with the world's leading laboratories, which allows us to perform unique genetic and metabolic studies.

In addition, it may be necessary to consult an endocrinologist, geneticist, and other specialists in particular areas, ultrasound, and other instrumental studies. Thanks to a comprehensive approach, our doctors can accurately identify the cause of infertility and choose effective methods for its elimination to restore fertility.

Prevention

The essence of infertility prevention due to mitochondrial dysfunction is the timely detection and elimination of the root cause, as well as conducting the necessary genetic tests when planning conception and during pregnancy. It is possible to reduce the risk of mitochondrial dysfunction by avoiding harmful working conditions and contact with toxic substances, timely treatment of infectious and inflammatory diseases.

Treatment of infertility due to mitochondrial disorders

At the VIVERE CLINIC, infertility treatment due to mitochondrial disorders is aimed at eliminating the underlying disease. Comprehensive therapy may include taking vitamins and medications and is chosen individually or by a Concilium of doctors after a comprehensive medical examination. We focus our efforts on restoring the function of the mitochondria, which allows the body to restore the ability to conceive and carry a fetus.

Recommendations

If you have not been able to conceive for more than 1 year and there are signs of mitochondrial dysfunction, you should make an appointment with your doctor. Timely diagnosis and treatment will not only help you to get pregnant but also to bear a healthy child. At VIVERE CLINIC you will receive help from highly qualified doctors, with an evidence-based, multidisciplinary approach.

Cost

How much it costs to diagnose and treat infertility due to mitochondrial disorders depends on a number of factors, in particular on the techniques and technology used. Since the examination and treatment program for each patient is chosen individually, the cost may vary. Prices for individual services of our clinic are listed in the price list.
You can make an appointment with a VIVERE CLINIC specialist by phone or online. 

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Лікуємо нашого хлопчика і бачимо позитивні результати, хлопчик став краще розмовляти, з'явився апетит, з'явилось бажання пробувати нові продукти, легше реагує на все, легше домовлятися. Дякую лікарю Володимиру Михайловичу Стефанишину.

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Елена Моцарь

Доброго дня! Нарешті я написала відгук, вже півроку з вами) Я мама дитини, яка до 18 років мала купу діагнозів, які і близько не мали відношення до нашої хвороби! Уявіть, скільки часу було витрачено... лікування ніяке (звісно) не допомагало, а ставало ще гірше. Доки нам не порекомендували Шейко Макар Васильовича! Сказати, що Він нам допоміг , це нічого не сказати! Макар Васильович врятував мою Софію! Завдяки правильній діагностиці, ми маємо НАШ діагноз (рідке орфанне захворювання) і правильне лікування. Я бачу поліпшення, моя дитина як заново народилася! Макар Васильович - це дбайлива і дуже чутна Людина, якій довіряєш! На прийомі немає оцього бар'єру лікар-пацієнт, ви як прийшли до друга, який вас підбадьорить, вислухає. Дуже рекомендую!

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