The Cunningham panel is a blood test that helps diagnose autoimmune neuropsychiatric syndromes caused by infection, including basal ganglia encephalitis and PANS/PANDAS

Panel Cunningham.

The Cunningham Panel™ is designed to determine the level of autoimmune antibodies associated with neuropsychiatric disorders and their ability to stimulate and trigger neurological behavior. An increase in the level of these antibodies indicates that the symptoms present in the child may be related to an autoimmune reaction caused by the infection.
The Cunningham panel enables the practitioner to identify the presence of infections, and therefore to treat these infections, rather than treat the existing condition as a mental illness.

The Cunningham panel is a series of specialized blood tests that help clinicians diagnose infection-induced autoimmune neuropsychiatric syndromes, such as basal ganglia encephalitis and PANS/PANDAS.
RANDAS – Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infection (pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection) is a syndrome that combines all neuropsychiatric symptoms in children with proven autoimmune infection.

PANS - Pediatric Acute-onset Neuropsychiatric Syndrome (pediatric acute-onset neuropsychiatric syndrome) is a syndrome that is also characterized by neuropsychiatric disorders in children, but in this case, causes that are usually not specifically related to streptococcus, but may include more than 200 different factors, including other bacteria, viruses or even tumors.

Lysoganglioside GM1 is found inside the membrane of nerve cells and plays an important role in the transmission of signals in the brain. It provides the vital function of communication between neurons and the correct transmission of impulses. When a patient's autoantibodies are directed against lysoganglioside, they can interrupt this connection and disrupt normal neurological activity. People with an elevated level of anti-lysoganglioside GM1 suffer from sleep disturbances, behavioral regression, obsessions, and anxiety states.

Tubulin is an intracellular protein that forms microtubules and provides a framework to maintain cell shape. Tubulin is found in every cell and is very common in brain structures. It plays an important role in cellular signaling and communication within the cell. When the patient's autoantibodies are directed against tubulin, obsessive-compulsive disorders and cognitive impairment occur.

Calcium/calmodulin-dependent protein kinase II (CaMKII) is a key enzyme involved in the activation of neurotransmitters (peptides that ensure the transmission of nerve impulses between neurons): dopamine, epinephrine, and norepinephrine. The CaMKII test performed in the Cunningham panel is a "cell stimulation assay." This test involves growing human brain cells in culture and incubating the patient's serum on these cells to determine whether the autoantibodies present bind to and stimulate this enzyme. If the patient's autoantibodies stimulate this enzyme, it can cause abnormal neurological, mental, and behavioral symptoms. Elevated levels of CaMKII activity are found in patients with involuntary movements, cognitive impairment, emotional lability, and other neuropsychiatric symptoms.

If you or your child has neurological symptoms, you should consult a specialist without wasting time.
The Cunningham Panel™ is a unique technique based on the results of more than 20 years of research. It is offered exclusively by Moleculera Labs, Inc. and is used by clinicians worldwide. The exclusive partner of Moleculera Labs is the neuroimmunology clinic Vivere.

Accurate diagnosis is the basis for forming the correct treatment strategy and optimal neurorehabilitation program for patients.

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