FRAT™ - a test for antibodies to folate receptors.

What is FRAT™?

FRAT is a proprietary diagnostic blood test that detects antibodies to folic acid receptor alpha (FRa). The FRAT™ is an important tool for assessing your child's neurological status. This is a simple test that allows you to get comprehensive results.

What is the role of antibodies targeting folic acid receptor alpha (FRa)?
These antibodies can be blocking, binding, or a combination, but all of them prevent the proper absorption of folate into critical tissues, such as the brain. In turn, folic acid deficiency in the brain is often found in children with autism.

How do antibodies to folate receptors affect the neurological condition?
The presence of antibodies to folic acid receptors indicates that folate (vitamin B9), which is an important vitamin, is not properly transported to the brain. It can contribute to neurodevelopmental disorders, including autism.

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Is folic acid important for the nervous system? 
Yes of course. Folic acid (vitamin B9) and its active form 5-MTHF are necessary for proper human growth and development. It is also necessary to maintain the health of the nervous system - it helps to protect and properly work the brain.

Lack of sufficient folic acid levels causes various neurological disorders, such as:

  • autism spectrum disorders;
  • cerebral folate deficiency (other names are cerebral folate deficiency, cerebral folate deficiency, folate cerebral deficiency);
  • neural tube defects;
  • subfertility;
  • pregnancy complications (miscarriage, prematurity).

Were antibodies to folate receptors detected in children diagnosed with ASD?
Thus, it was found that 70% of children with autism spectrum disorders have these antibodies.

How will FRAT™ help me?

FRAT™ will confirm the presence of antibodies to folate alpha receptors, which may indicate that insufficient amounts of folate are being transported to the brain.
Folic acid deficiency can often be corrected by administration of active folate metabolites that bypass the blocking/binding receptors.

Is there scientific evidence to support these claims?
Yes, there are many publications that describe in detail the effect of antibodies to folate receptors in a number of neurological disorders. 

What else should I know about FRAT™?
FRAT™ is a proprietary test performed in a CLIA-certified laboratory. This test is important for children with autism of different ages. We recommend early testing. FRAT™ antibody screening offers doctors and parents a new way to treat disorders masquerading as autism spectrum disorders.

How to prepare for the analysis?
For 48 hours before taking the material, you should stop taking preparations containing folic acid, folinic acid and 5-MTHF.
Parents should pay attention to the folic acid content in children's food products (baby formula).
When using immunoglobulin therapy, material for testing is collected no earlier than 2-3 months after the drug is administered.


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Доброго дня! Нарешті я написала відгук, вже півроку з вами) Я мама дитини, яка до 18 років мала купу діагнозів, які і близько не мали відношення до нашої хвороби! Уявіть, скільки часу було витрачено... лікування ніяке (звісно) не допомагало, а ставало ще гірше. Доки нам не порекомендували Шейко Макар Васильовича! Сказати, що Він нам допоміг , це нічого не сказати! Макар Васильович врятував мою Софію! Завдяки правильній діагностиці, ми маємо НАШ діагноз (рідке орфанне захворювання) і правильне лікування. Я бачу поліпшення, моя дитина як заново народилася! Макар Васильович - це дбайлива і дуже чутна Людина, якій довіряєш! На прийомі немає оцього бар'єру лікар-пацієнт, ви як прийшли до друга, який вас підбадьорить, вислухає. Дуже рекомендую!

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Treatment of children with ASD PANS/PANDAS/PITANS treatment Treatment of opportunistic infections Treatment of immune deficiencies Treatment of dermatoses of various etiologies (acne, rosacea, dermatitis) Treatment of fungal and viral diseases (herpes, warts, molluscum contagiosum), allergic dermatosis, streptoderma, eczema, atopic dermatitis Treatment and support of chronic dermatoses in order to prolong remission periods and reduce the number of relapses

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  • Canada
  • USA
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  • United Kingdom
  • Spain
  • Netherlands
  • Belgium
  • Germany
  • Switzerland
  • Italy
  • Czech Republic
  • Austria
  • Croatia
  • Bosnia and Herzegovina
  • Albania
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  • Serbia
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  • Sweden
  • Finland
  • Poland
  • Belarus
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  • Georgia
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  • Kazakhstan
  • Uzbekistan
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