presence of antibodies to the folate transporter receptor — FRAT-positive folate deficiency
Infertility due to folate deficiency
The delivery of folic acid and folate (active forms of folic acid) via specific receptors plays an important role in reproductive processes. The central nervous system and the reproductive organs are particularly dependent on folate.
When this mechanism is disrupted, there is damage to the DNA, deterioration of the quality of eggs and sperm, resulting in difficulties in conceiving a child and maintaining a pregnancy. This is why infertility often develops due to folate deficiency, in which there is a decrease in the concentration of folic acid in the tissues of the body.
Symptoms and peculiarities of manifestation
The main symptom of infertility due to folate deficiency is difficulty in conceiving for 1 year or longer. In some clinical cases the pregnancy ends in a spontaneous abortion at an early stage, so the woman does not even suspect conception.
It is worth noting that women with FD may have various neurological dysfunctions and mood disorders as a result of antibodies to the folate transporter receptor. If these symptoms are detected, you should immediately consult a physician for a comprehensive examination.
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Reasons
When folate deficiency develops, the bioavailability of folic acid is impaired as a result of antibodies to the folate transporter receptor. The most common reason is that the immune system produces autoantibodies to the folic acid receptor. This disturbs its absorption by the body, which leads to a deficiency. At the same time, folic acid is actively involved in cell division and embryogenesis, so its deficiency leads to infertility or spontaneous abortions in early gestation.
Diagnostic methods
When infertility is suspected due to cerebral folate deficiency, the VIVERE CLINIC performs a comprehensive evaluation, which may include
1. Examination of the patient, study of complaints and anamnesis, clarification of information about relatives, hereditary diseases.
2. Folic acid receptor antibody test to confirm the diagnosis.
3. Instrumental and laboratory tests that help evaluate the reproductive system and determine the cause of cerebral folate deficiency.
At VIVERE CLINIC you can undergo all the necessary examinations and laboratory tests, including specific methods. Based on their results, doctors are able to accurately determine the cause of the absence of conception, which is very important in the further choice of therapeutic tactics.
Prevention
To prevent infertility due to FD caused by antibodies to the folate transporter receptor, it is important to detect the disease in time and undergo treatment to eliminate the cause of this pathology. You should also follow all the doctor's recommendations, in particular, follow the prescribed diet.
Treatment of infertility due to FD because of antibodies to the folate transporter receptor
At the VIVERE CLINIC, infertility treatment due to CFD is carried out using advanced methods with proven efficacy. The therapy aims to eliminate the cause and create optimal conditions for conception and fetal development. For this purpose, high doses of a specific form of folic acid, immunosuppressants, immunoglobulins, and other drugs are prescribed. The complex treatment is compiled by a Concilium of doctors based on the results of the examination individually for each patient.
Recommendations
If a regular sexual life without contraception does not conceive for more than 1 year, or miscarriages occur in early pregnancy, it is important not to delay a visit to the doctor. The comprehensive examination can detect the cause, and correctly chosen treatment — to eliminate it and thereby increase the chances of pregnancy by 70-80%. You can make an appointment at our clinic right now at a time that is convenient for you.
Cost
You can have a Check-Up at the VIVERE CLINIC for the diagnosis and treatment of infertility due to FN caused by antibodies to the folate transfer receptor. Additional screening programs are prescribed only after consultation with the clinic's specialist doctors.
We don't use standard programs, but rather select a personalized regimen for each patient, taking into account a variety of individual factors. This approach allows us to find the cause, eliminate infertility and make the patient feel the happiness of motherhood. You can find out the approximate cost of treatment from your doctor during an appointment.
You can make an appointment by phone or through a form on the website.
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