Personalized Microbiome Therapy

The human microbiota is a complex ecosystem of billions of microorganisms that affects not only digestion, but also the functioning of the immune, nervous, and endocrine systems. Today, an increasing number of studies confirm the existence of the “gut–immune system–brain axis,” meaning that changes in the composition of the microbiota may be associated not only with gastrointestinal symptoms, but also with impaired immune responses, chronic inflammation, chronic fatigue syndrome, neuroinflammatory processes, and certain neuroimmunological disorders.

For this reason, the modern approach to microbiota correction is no longer limited to prescribing a random probiotic from a pharmacy. At VIVERE Clinic, we use personalized microbiome therapy — an individualized approach aimed at restoring the natural balance of the microbiota while taking into account the specific patient’s characteristics, underlying condition, immune status, and laboratory diagnostic results.

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Personalized Probiotic Selection: What Does It Mean?

There is no universal probiotic that is equally effective for everyone. Each probiotic strain has its own biological properties, mechanisms of action, and level of scientific evidence. That is why personalized probiotic selection begins not with choosing a product, but with identifying the causes of microbiota imbalance.

In many cases, the problem is not a lack of “beneficial bacteria,” but rather the excessive growth of certain opportunistic microorganisms or an imbalance between different members of the microbiome. The physician’s task is to understand what specific changes have occurred and which correction strategy will be the most physiological and effective.

Personalized microbiome therapy involves the individual selection of strains capable of interacting with each other and with the patient’s microbiota, thereby promoting its gradual restoration.

Why a Personalized Probiotic Differs from a Standard One

The main idea of personalized microbiome therapy is not simply to add “beneficial bacteria” to the body. Much more important is creating conditions in which the normal microflora can restore balance on its own and begin controlling the growth of undesirable microorganisms.

For this purpose, specially selected probiotic strains with antagonistic properties are used. They can compete with opportunistic flora for nutrients and attachment sites on the mucosal surface, synthesize bacteriocins, organic acids, and other biologically active substances that inhibit the growth of certain bacteria or fungi. As a result, conditions are created for the natural restoration of the intestinal ecosystem without aggressive intervention.

That is why, in certain clinical situations, a personalized probiotic may become an alternative to the unjustified use of antibiotics or antifungal medications when there are no signs of an infectious process requiring specific therapy. However, if a bacterial or fungal infection is confirmed, probiotics do not replace etiological treatment; they are used as one of the components of comprehensive microbiota recovery after the main therapy has been completed.

This approach makes it possible to address not only symptoms, but also the ecology of the microbiome by restoring its natural mechanisms of self-regulation.

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When Is Probiotic Selection Based on Laboratory Tests Necessary?

Personalized microbiome therapy may be recommended for patients after repeated courses of antibiotic therapy, in cases of irritable bowel syndrome, bloating, constipation or diarrhea, recurrent intestinal infections, prolonged digestive disorders, as well as certain immunological and neuroimmunological conditions.

This approach is of particular interest for patients with chronic fatigue syndrome, PANS/PANDAS, autoimmune diseases, and other conditions in which increasing attention is being paid to the interaction between the microbiota, the intestinal barrier, and the immune system.

If necessary, the physician may order laboratory tests to assess the functional state of the body, inflammatory activity, characteristics of the immune response, or other factors that may affect the microbiome. At the same time, there is no universal test that determines the “correct” probiotic. All results are interpreted only in conjunction with the clinical picture.

What Results Can Personalized Microbiome Therapy Provide?

When the indications are correctly identified, personalized microbiota correction may help normalize digestion, reduce bloating, restore regular bowel movements, improve the intestinal barrier function, and support the physiological functioning of the immune system.

Since the intestine is one of the central elements of the interaction between the microbiota, the immune system, and the brain, restoring its ecosystem may positively affect overall well-being, exercise tolerance, and the course of certain neuroimmunological disorders. At the same time, personalized microbiome therapy is not considered a universal treatment method and is always part of a comprehensive medical approach.

Advantages of Personalized Microbiome Therapy at VIVERE Clinic

At VIVERE Clinic, we view the microbiota as an important component of the unified “gut–immune system–brain” axis. Therefore, decisions regarding probiotic therapy are not made according to a standard template, but after a comprehensive assessment of the clinical situation, examination results, and current scientific evidence.

Our approach is based on the principles of evidence-based medicine and personalized therapy. We do not prescribe the same products to all patients, and we do not treat laboratory results in isolation. Instead, we identify the mechanisms underlying microbiota imbalance, assess their relationship with the immune and nervous systems, and develop an individualized treatment program that may include personalized selection of probiotic strains, dietary correction, support of the intestinal barrier function, and other modern microbiome therapy methods.

This is precisely the approach that allows us not only to temporarily reduce symptoms, but also to address the underlying causes of microbial ecosystem imbalance and support long-term restoration of health.

How the Consultation and Individual Selection Are Conducted

  1. The consultation begins with a detailed review of the medical history. The physician evaluates dietary habits, previous infections, prior treatments, antibiotic use, the presence of autoimmune or allergic diseases, immune system status, lifestyle, and factors that may have influenced the composition of the microbiota.
  2. After that, an individualized examination plan is developed and the treatment strategy is determined. In some cases, dietary or lifestyle modifications are sufficient. In others, personalized selection of probiotic strains, prebiotics, or other microbiome therapy methods is used.
  3. The goal of treatment is not to prescribe the maximum number of medications, but to restore the natural balance of the microbiota and eliminate the causes of its disruption.

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Протягом останнього року консультувалися з Макаром Васильовичем Шейко з приводу діагнозу та подальшої тактики лікування доньки. Отримали вичерпні відповіді на свої запитання, та насправді кваліфіковану допомогу. Можу сміливо радити лікаря як фахівця, що призначить лише потрібний обсяг досліджень, максимально глибоко та експертно оцінить результати - вважаю, саме в цьому полягає основна цінність консультації. І найголовніше - при зовнішній стриманості та небагатослівності, Макар Васильович дійсно переймається результатом лікування і прагне допомогти дитині, а не просто призначити препарати за протоколом. Щиро вдячна лікарю та клініці, сподіваюсь, з Вашою допомогою зможемо отримати добрі результати.

Світлана

Хочеться щиро подякувати Шейко Макару Васильовичу! За допомогу в вирішенні, лікуванні та правильному встановленню діагнозу нашої хвороби! Бо як виявилось сама більша проблема в тому щоб правильно встановити саме діагноз. Пред історія така .В дитини (14 років) в один прекрасний день опускається повіка, діагнозів в Охматдиті нам ставили багато, робили безліч обстежень але все марно ,поки шукали підтвердження, повіка самостійно піднялася. На цьому нам сказали все, пройшло і нічого не бачимо, можливо перехідний вік, як стане гірше звертайтесь. Так через місяць стало гірше, опускається ще одна повіка і додається двоїння в очах, швидка стомлюваність. Що ми пережили один Бог знає. Слава Богу що нам порадили клініку VІVERE, там ми потрапили на прийом до Макара Васильовича, чесно за пів години нам попередньо поставили діагноз (ми 4 місяці бігали по різних спеціалістах) а саме Мітохондріальна дисфункція, потрібно ще було доздавати аналізи. І відразу назначили лікування. Моєму подиву не було меж після першого прийому ліків призначених в дитини відразу стабілізувався стан очей, на протязі тижня пройшло двоїння (диплопія), дитина ожила. Відповідно ми ще лікуємось але дуже дякуємо за компетентність, уважність і правильний підхід.

Леся

Лікуємо нашого хлопчика і бачимо позитивні результати, хлопчик став краще розмовляти, з'явився апетит, з'явилось бажання пробувати нові продукти, легше реагує на все, легше домовлятися. Дякую лікарю Володимиру Михайловичу Стефанишину.

Юрій

В клинике уютно и светло. Приятно удивляет всегда быстрое реагирование на вопросы и просьбы девушек-регистраторов, их доброжелательное отношение. Ни один вопрос в вайбере не остался без ответа. Дважды были с сыном на консультации у Шейко Макара Васильевича. Неординарный, профессиональный и, в то же время, душевный, можно сказать дружеский подход, к решению проблем пациента, у Макара Васильевича. Также 2 года назад мы были на приеме у иммунолога Мельник Леси Игоревны. Остались тоже очень довольны. Впечатлило глубокое понимание проблемы, а также достаточно доступное объяснение и интересное изложение информации.

Елена Моцарь

Доброго дня! Нарешті я написала відгук, вже півроку з вами) Я мама дитини, яка до 18 років мала купу діагнозів, які і близько не мали відношення до нашої хвороби! Уявіть, скільки часу було витрачено... лікування ніяке (звісно) не допомагало, а ставало ще гірше. Доки нам не порекомендували Шейко Макар Васильовича! Сказати, що Він нам допоміг , це нічого не сказати! Макар Васильович врятував мою Софію! Завдяки правильній діагностиці, ми маємо НАШ діагноз (рідке орфанне захворювання) і правильне лікування. Я бачу поліпшення, моя дитина як заново народилася! Макар Васильович - це дбайлива і дуже чутна Людина, якій довіряєш! На прийомі немає оцього бар'єру лікар-пацієнт, ви як прийшли до друга, який вас підбадьорить, вислухає. Дуже рекомендую!

Анна
Volodymyr Monastyrsky
My motto in life is to do everything consciously, in a structured way, and with maximum attention to the process. Neurology is a specialty where details are important.

- Parkinson's disease; - epilepsy and seizure syndromes; - multiple sclerosis and encephalomyelitis; - vascular neurology (strokes and their consequences, cerebral atherosclerosis, arterial hypertension); - demyelinating, inflammatory, and degenerative diseases of the nervous system; - dementia; - the effects of a traumatic brain injury; - migraine; - polyneuropathy; - neuroinfections; - encephalitis and its consequences.

Volodymyr Monastyrsky
Neurologist of the highest category, candidate of medical sciences

Stage: 20 years

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Nataliіa Samonenko
Nataliіa Samonenko

- accumulation diseases; - congenital anomalies of the eye, ear, face and neck, urinary system, nervous system, respiratory system, digestive system, circulatory system; - anemia; - congenital anomalies and deformations of the musculoskeletal system; - hereditary anomalies; - congenital iodine deficiency syndrome; - Preconception prevention; - Prenatal diagnosis; - DNA testing; - Diagnosis and treatment of metabolic diseases

Nataliіa Samonenko
Geneticist of the highest category, pediatrician

Stage: 25 years old

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Bukulova Nana
Responsibility, structure, individual approach to everyone.

- irritable bowel syndrome - helminthiasis - inflammatory bowel diseases (Crohn's disease, ulcerative colitis) - constipation - diarrheal syndrome - digestive diseases - congenital intestinal anomalies

Bukulova Nana
Gastroenterologist, pediatric gastroenterologist, pediatrician, ultrasound diagnostician, candidate of medical sciences

Stage: 17 years

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Olga Selezneva
The first step toward solving a problem is to realize that it exists

Electroencephalography (EEG) in children and adults for differential diagnosis of seizures and epileptiform states in various diseases, as well as dynamic monitoring during specific therapy.

Olga Selezneva
Functional diagnostics doctor of the highest category, neurologist

Stage: 34 years

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Makar Sheiko
Changing Psychiatry Together

The doctor is now helping not only our patients but also our country. We support him and look forward to his return!

Makar Sheiko
Medical Director of VIVERE Clinic Highest-category psychiatrist and geneticist

Stage: 20 years

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Vivere International is a chance for every patient from every corner of the world to get expert help in diagnosing and treating such diseases as autism spectrum disorders, PANS/PANDAS syndrome, chronic fatigue syndrome, depression-anxiety disorders, autoimmune encephalitis, dementia, and other diseases caused by metabolic and neuroimmunological disorders in children and adults.

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Our clinic has a multidisciplinary team of professionals, who use the latest evidence-based treatment protocols that have proven to be effective.

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  • Canada
  • USA
  • Ireland
  • Portugal
  • United Kingdom
  • Spain
  • Netherlands
  • Belgium
  • Germany
  • Switzerland
  • Italy
  • Czech Republic
  • Austria
  • Croatia
  • Bosnia and Herzegovina
  • Albania
  • Greece
  • Hungary
  • Serbia
  • North Macedonia
  • Sweden
  • Finland
  • Poland
  • Belarus
  • Moldova
  • Ukraine
  • Turkey
  • Cyprus
  • Georgia
  • Azerbaijan
  • Saudi Arabia
  • UAE
  • Kazakhstan
  • Uzbekistan
  • South Korea
  • Australia